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KMID : 0614620120600030177
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Korean Journal of Gastroenterology
2012 Volume.60 No. 3 p.177 ~ p.181
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A Case of Severe Acute Hepatitis A Complicated with Pure Red Cell Aplasia
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Yim Pyeong-Suk
Kim In-Hee
Kim Seong-Hun
Lee Seong-Ok
Kim Sang-Wook
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Abstract
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Hepatitis A is typically a self-limited acute illness that does not progress to chronic hepatitis. In rare cases, acute hepatitis A can be associated with serious complications (such as fulminant hepatitis or acute kidney injury) and may result in death or liver transplantation. Pure red cell aplasia (PRCA) is a rare hematologic disorder characterized by anemia, reticulocytopenia in the blood, and isolated erythroblastopenia with normal granulopoiesis and megakaryopoiesis in the bone marrow. PRCA is a rare hematopoietic complication of acute viral hepatitis, and few cases associated with hepatitis A virus infection have been reported. Recently, we experienced a case of severe hepatitis A complicated by fulminant hepatitis and acute kidney injury followed by PRCA which showed a favorable response to oral corticosteroids.
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KEYWORD
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